One of our objectives is to understand the interplay between innate and adaptive immunity in chronic viral infections, in order to identify mechanisms responsible for the lack of immune control of persistent viruses, such as HIV or HPV. In particular, we dissect the modalities of the cross-talk between some innate effectors, i.e. dendritic cells (DCs) and natural killer (NK) cells, and their impact on adaptive immunity. Moreover, we have been involved in the search for new pathways of HIV entry and we contributed to show the implication of purinergic receptors in the process of fusion mediated by HIV-1-envelope. Finally, we have set up an Immunomonitoring Platform evaluating, in phase I and II vaccine trials, the immunogenicity of new vaccine candidates specific for influenza, malaria, shigellosis, anthrax or cancer.
ANR “Organismes pathogènes, infections, immunité”
“Large-scale genomic re-encoding of RNA viruses for producing live-attenuated vaccine candidates” (RNA Vacci-Code)
Antiviral Immunity, Biotherapy And Vaccines
One of our objectives is to understand the interplay between innate and adaptive immunity in chronic viral infections, in order to identify mechanisms responsible for the lack of immune control of persistent viruses, […]
INCEPTION – Institut Convergence for the study of Emergence of Pathology Through Individuals and Populations
IINCEPTION Goal The Inception’s goal is to develop a core structure to mobilize data resources, numerical sciences, and fundamental experimental biology in a range of health issues (Official website here : https://www.inception-program.fr/en). Inception program […]
2020Targeting Macrophage Histone H3 Modification as a Leishmania Strategy to Dampen the NF-κB/NLRP3-Mediated Inflammatory Response., Cell Rep 2020 Feb; 30(6): 1870-1882.e4.
2019Trans-Atlantic Spill Over: Deconstructing the Ecological Adaptation of Leishmania infantum in the Americas., Genes (Basel) 2019 12; 11(1): .
2019Author Correction: Discovery of novel hit compounds with broad activity against visceral and cutaneous Leishmania species by comparative phenotypic screening., Sci Rep 2019 Jul; 9(1): 10148.
2017HMGB1/anti-HMGB1 antibodies define a molecular signature of early stages of HIV-Associated Neurocognitive Isorders (HAND), Heliyon 2017 Feb;3(2):e00245.
2014Causal analysis of H1N1pdm09 influenza infection risk in a household cohort, J Epidemiol Community Health 2015 Mar;69(3):272-7.
2014Peripheral and local human papillomavirus 16-specific CD8+ T-cell expansions characterize erosive oral lichen planus, J. Invest. Dermatol. 2015 Feb;135(2):418-24.
2014Suppression by thimerosal of ex-vivo CD4+ T cell response to influenza vaccine and induction of apoptosis in primary memory T cells, PLoS ONE 2014;9(4):e92705.
2014Thimerosal compromises human dendritic cell maturation, IL-12 production, chemokine release, and T-helper polarization, Hum Vaccin Immunother 2014;10(8):2328-35.
2013Clinical validation of IFNγ/IL-10 and IFNγ/IL-2 FluoroSpot assays for the detection of Tr1 T cells and influenza vaccine monitoring in humans, Hum Vaccin Immunother 2014;10(1):104-13.
2013Analysis of NKp30/NCR3 isoforms in untreated HIV-1-infected patients from the ANRS SEROCO cohort, Oncoimmunology 2013 Mar;2(3):e23472.
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