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  • Director of Center
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© Institut Pasteur
Structure de macromolécules : dimère d'aquométhémoglobine de cheval. Dérivé toxique oxydé de l'hémoglobine, représentant 1 à 2% du total.
Service

Thermodynamical stability of macromolecules

Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
03
Apr 2015
Status
Ongoing
Members
2
Structures
1

About

Circular dichroism (CD) spectroscopy allows the determination of secondary and tertiary structures, the analyse of conformational changes, the kinetic of folding and the measure of thermal and chemical stability of folding.

aviv300

Differential Scanning Calorimeter (DSC) give access to the thermal stability of macromolecules and their complexes
microdsc260

Access Protocol

Equipments on the PFBMI are available for the entire scientific community, national and international, but a priority is given at Institut Pasteur and Institut Pasteur International Network.
The PFBMI is performing the analysis as one goes along their reception (biophysique@pasteur.fr). An inital form (upload here) must be joined.

Equipments

Circular Dichroism • AVIV • 215

The PFBMI has an Aviv 215 instrument with accessories for the measurement of total fluorescence and to perform titrations. Studying macromolecules (and in particular proteins) by circular dichroism allows to obtain information about their […]

Infrared spectroscopy (FTIR) • Jasco • 6100

Fourier Transform Infra Red (FTIR) spectroscopy allows to analyze the secondary structure of macromolecules by measuring absorption frequencies of some specific chemical groups (notably, for proteins, that of the amide bond). Informations given by FTIR are […]

Microcalorimetry (DSC: Differential Scanning Calorimetry) • Malvern • CAP-DSC

Microcalorimetry enables the thermodynamic characterization of molecular interactions in solution, and of biochemical reactions in general. The Capillary Differential scanning calorimeter (CAP-DSC, Malvern) is principally dedicated to the study of the thermal stability of […]