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© Fabrice Chrétien with Ultrapole, colorized by Jean-Marc Panaud
Cellule souche (en jaune) de muscle squelettique partiellement recouverte par la membrane basale, migrant sur une fibre musculaire (en bleu).
Starting Date
19
Nov 2015
Status
Ongoing
Members
8
Structures
1

About

About us

Our laboratory offers state-of the art large histotechnological laboratory with a team of specialized Engineers and histopathologists from medical and veterinary education. Our unit are available for collaborative research. Many projects are currently ongoing on animal models of infectious diseases, cancer, immunotherapy or inflammation with internal or external research teams. Individuals wishing to develop collaborative research efforts are encouraged to contact us when developing research projects. Optimal results are obtained when the staff is contacted as early as possible in the conception of the in vivo part of the project; this allows us to help determine how histological approach can best support the research aim.


Range of services

A variety of pathology services can be provided to research investigators:

  • Necropsy & gross examination of animal tissues
  • Design of the protocol
  • Methodology advice on proper tissue collection
  • Choice of morphological approaches (fixation, embedding, slide preparation, slide treatments)
  • Evaluation of the slides including description, semi-quantitative scoring and morphometric analysis
  • Histopathology report with microphotographs
  • Discussion of the results
  • Recommendations for further experiments

Technics

Our Histology laboratory prepares slides and a wide variety of quality, flexible histopathological and immunohistochemical stains for investigative staff. We also develop new technical tools for animal tissue analysis:We also have access to Safety level 3 facility for frozen sectioning of infected human or animal tissues.


Terms of collaboration/authorship

Our scientific contribution is free-of-charges but collaborators will be asked to share the cost of histological techniques. Engineers and Pathologists who contributed to the project must be listed as co-authors and Technicians in acknowledgement.

Access Protocol

Equipments

Cryostat • LEICA • CM 3050S

This material is needed  to perform frozen sections.  People trained in frozen sectioning  from other laboratories can use this material under our supervision. Please contact us 

Cryostat in Safety level 3 facility • LEICA • CM 3050S

This material allows us to perform frozen sections from human or animal samples infected with safety level 3 pathogens. Please contact us if needed

Microtome • LEICA • RM 2245

A microtome is needed to perform paraffin sections. Trained people from other laboratories can have access to this equipment under our supervision Please contact us if needed  

Vibratome • LEICA • VT 1200S

Vibrating microtomes (vibratomes) allows to cut tissues without freezing or embedding. 50-100 um sections can be performed to study the tissue morphology in 3D or to preserve enzyme and cell activities within thick slices. […]

Automated tissue processor • LEICA • TP 1050

This material is needed for routinely dehydration and pre-embedding of tissue samples in paraffin. We can perform the pre-embedding of your tissue samples Please contact us if needed

Automated slide stainer • MICROM • HMS 740

This automat provides reproducible automated, high quality standard stainings for paraffin or frozen histological sections. Please contact us if you need to stain histological sections (Hematoxylin-Eosin or special stains) Please contact us if needed

Paraffin embedding station • LEICA • EG 1150

The paraffin embedding station is needed to routinely prepare paraffin blocks. We can perform the embedding of your tissue samples Please contact us if needed

Slide scanner • ZEISS • Axio Scan.Z1

The Axio Scan allow to digitize histological sections and  create high-quality virtual slides. Both bright field and fluorescent sections can be digitalized. Virtual slides can be then be kept and observed or used for […]

Digital camera • NIKON • DSRi2

High quality bright field microphotographs can taken with this material, which is connected to a NIKON 50i microscope. People from other laboratories can have access to this equipment Please contact us if needed