Description: Duration of cellular and humoral immune response in past PEP recipients exposed to RABV? dogs (at 1, 2, 5 and 10 years)
It is likely that patients respond equally well within days following a 3-session post-exposure prophylaxis regimen as they do after the currently recommended 4-session protocols. This is being
tested prospectively by the RESIST-2 study. But even if response is comparable between groups in the short term, a lower dose and shorter initial protocol may adversely affect the persistence of
antibodies after several months or years.
We propose to call back persons who referred several years ago at IPC’s rabies prevention center for intradermal post-exposure prophylaxis following a potentially infective bite. Some received the recommended 4-session protocols after being bitten by rabies-confirmed dogs while other interrupted the protocol early after one week/3 sessions, not referring for the 4th session at D28 due to financial constraints linked with transportation costs.
Goal: To assess the level and duration of antibody protection as determined by RFFIT testing in patients bitten by rabid dogs, by level of protocol completion (3 versus 4 session) and ERIG use. The aim of the tests will be to assess % antibody-positives and mean of antibody titer after 3 sessions compared to 4 sessions, one or several years ago.