Description: Although WHO has estimated that 36% of neonatal mortality is directly attributable to severe bacterial infections in LICs, those infections are little documented. Moreover, antimicrobial resistance is now recognized as an emergent major issue in developing countries but little research, has been conducted on resistance profiles of bacteria causing infections in young children in these countries.
Goal: The aim of this prospective study is to estimate the incidence of bacterial infections and of their antimicrobial resistance to antibiotics: neonatal infections (<28 days of life), infections in infants and young children (28 days to <2 years). Secondary aims are : To estimate the incidence of bacterial neonatal infections (both sensitive and resistant to antimicrobials); to describe the bacterial etiologies and severity of neonatal infections in LICs ; To assess the vertical transmission of multi-resistant bacteria from mother-to-child, versus infections contracted via the environment and from relatives; To analyze the medical and economic burden of antimicrobial resistance, in view of the available treatments and current therapeutic recommendations in Cambodia.
ContributorsInstitut Pasteur in Paris
Institut Pasteur in Cambodia
Epidemiology Unit, Institut Pasteur du Cambodge