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About

-MSc, PhD

Project Summary: I am manager of the 4-years group (G4) in Bioinformatics and Biostatistics applied to infectious diseases. As mathematician specialized in statistical genetics, my research project aims at identifying the environmental factors and the genetic factors as well as their interactions implicated in malaria and arboviral infections and in the various clinical manifestations of these diseases. The estimation of key environmental and genetic parameters contributes to better understand the emergence and maintenance of these diseases by their inclusion in the mathematical modeling of infections dynamics. Analyses of epidemiological and clinical data are being performed using generalized regression methods and data mining depending on the data design and on the distribution of the traits under study. The study of host genetic factors is conducted by the development and the application of multi-makers association methods over the whole genome. These methods are particularly suited to complex multifactorial traits, such as those related to infectious diseases These methods can include biological knowledge such as gene expression data, interactions between proteins (Pathways, Gene co-expression and protein-protein interactions networks based Genome-Wide Association Studies). The modeling of the dynamics of infections will be performed using compartmental models for vector-borne pathogens. The G4 consists of researchers specialized in biostatistics and bioinformatics working closely with local IPD’s research units for, e.g., the definition of study designs, the development of new methods and proposal of programs for data analysis.

Events

“Decoding toxin-parasite interactions in Trypanosomatids”

Building: Lwoff – Room: Retrovirus – Address: Institut Pasteur, Rue du Docteur Roux, Paris, France
2015-10-08 12:00:00 2015-10-08 13:00:00 Europe/Paris “Decoding toxin-parasite interactions in Trypanosomatids” Sam ALSFORD – London School of Hygiene & Tropical Medicine (Londres – Royaume Uni) The development of high-throughput RNA interference screening technology in the protozoan parasite Trypanosoma brucei has enabled us to identify many […] Institut Pasteur, Rue du Docteur Roux, Paris, France

“Parasitology in the 21st century”

Building: Duclaux (01) – Room: Amphithéâtre Duclaux – Address: Institut Pasteur, Rue du Docteur Roux, Paris, France
2015-11-23 03:20:07 2015-11-24 18:00:00 Europe/Paris “Parasitology in the 21st century” Keynote speakers: Carolina V. Barillas-Mury & Piet Borst Speakers: Cyrille Botté, Markus Engstler, Richard Grencis, Michael Grigg, Mohamed-Ali Hakimi, Cynthia He, Matthew Higgins, David Horn, Patricia Johnson, Shaden Kamhawi, Hugo Lujan, Julius Lukes, Geoff […] Institut Pasteur, Rue du Docteur Roux, Paris, France

“Research on Malaria transmission stages”

Building: Lwoff – Room: Retrovirus – Address: Institut Pasteur, Rue du Docteur Roux, Paris, France
2015-12-16 00:00:12 2015-12-16 13:00:00 Europe/Paris “Research on Malaria transmission stages” Jetsumon PRACHUMSRI – Mahidol University, Faculty of Tropical Medicine (Bangkok – Thaïlande) Malaria research at MVRU has focused on parasite biology and transmission as well as host-parasite interaction in Thailand and in the region. […] Institut Pasteur, Rue du Docteur Roux, Paris, France

“Breadth of the humoral response and antigenic targets associated with protection following experimental Plasmodium falciparum sporozoite inoculation in humans”

Building: Lwoff – Room: Retrovirus – Address: Institut Pasteur, Rue du Docteur Roux, Paris, France
2015-12-17 00:00:12 2015-12-17 13:00:00 Europe/Paris “Breadth of the humoral response and antigenic targets associated with protection following experimental Plasmodium falciparum sporozoite inoculation in humans” Laurent RENIA – Singapore Immunology Network (SIgN), Agency for Science, Technology, and Research (A*STAR) (Singapour – République de Singapour) The development of an effective malaria vaccine has remained elusive till today. This is in […] Institut Pasteur, Rue du Docteur Roux, Paris, France

“Trans-splicing and RNA modification regulate the life and death of Trypanosoma brucei”

Building: Lwoff – Room: Retrovirus – Address: Institut Pasteur, Rue du Docteur Roux, Paris, France
2016-01-07 12:00:00 2016-01-07 13:00:00 Europe/Paris “Trans-splicing and RNA modification regulate the life and death of Trypanosoma brucei” Shulamit MICHAELI – Bar Ilan University (Ramat Gan – Israel) In the seminar I will report on the discovery and the mechanism of the spliced leader silencing (SLS) pathway which is induced under ER […] Institut Pasteur, Rue du Docteur Roux, Paris, France

“High throughput approaches to understanding Plasmodium erythrocyte invasion”

Building: Lwoff – Room: Retrovirus – Address: Institut Pasteur, Rue du Docteur Roux, Paris, France
2016-01-21 00:00:12 2016-01-21 13:00:00 Europe/Paris “High throughput approaches to understanding Plasmodium erythrocyte invasion” Julian RAYNER – Wellcome Trust Sanger Institute (Cambridge – Royaume-Uni) More than a decade after the completion of the first Plasmodium genome, nearly a third of that genome remains annotated as hypothetical genes with […] Institut Pasteur, Rue du Docteur Roux, Paris, France

“Protection against malaria is induced by blood stage-arresting Histamine Releasing Factor (HRF)-deficient Plasmodium parasites”

Building: Lwoff – Room: Retrovirus – Address: Institut Pasteur, Rue du Docteur Roux, Paris, France
2016-01-28 12:00:00 2016-01-28 13:00:00 Europe/Paris “Protection against malaria is induced by blood stage-arresting Histamine Releasing Factor (HRF)-deficient Plasmodium parasites” Claudia DEMARTA-GATSI – Unité de Biologie des interactions hôte-parasite (BIHP) Whole parasite vaccines such as genetically attenuated parasite (GAP) vaccines that induce cross-stage, long-lasting sterile protection have become the state-of-the-art to target malaria for […] Institut Pasteur, Rue du Docteur Roux, Paris, France

“Avian malaria and the evolutionary ecology of host-parasite interactions”

Building: Lwoff – Room: Retrovirus – Address: Institut Pasteur, Rue du Docteur Roux, Paris, France
2016-02-04 12:00:00 2016-02-04 13:00:00 Europe/Paris “Avian malaria and the evolutionary ecology of host-parasite interactions” Ana RIVERO  – Institut de Recherche pour le Développement (Montpellier – France) Avian malaria is the oldest experimental system for investigating the biology and transmission of Plasmodium parasites. It was the model used by […] Institut Pasteur, Rue du Docteur Roux, Paris, France

Scientific Day on Genome Editing Technology : CRISPR-Cas9 Seminar

Building: Monod (66) – Room: Amphithéâtre – Address: Institut Pasteur, Paris, France
2016-02-11 10:00:00 2016-02-11 00:00:00 Europe/Paris Scientific Day on Genome Editing Technology : CRISPR-Cas9 Seminar 10:00 – 11:00 : Fundamental and innovations in CRISPR-Cas9 gene editing James Goldmeyer, PhD, Product Manager GE Healthcare Dharmacon 11:00 – 11:30 : iCRISPR: inducible editing in stem cells and their derivatives Janine Scholefield, […] Institut Pasteur, Paris, France

“The impact of hotspot targeted interventions on malaria transmission: an example of different scientific disciplines investigating public health solutions”

Building: Lwoff – Room: Retrovirus – Address: Institut Pasteur, Rue du Docteur Roux, Paris, France
2016-02-18 12:00:00 2016-02-18 13:00:00 Europe/Paris “The impact of hotspot targeted interventions on malaria transmission: an example of different scientific disciplines investigating public health solutions” Amrish BAIDJOE – Institut Pasteur, Département de Virologie (Paris – France) Although malaria is a disease that till date still causes significant mortality and morbidity mostly among children, impressive reductions in prevalence have been […] Institut Pasteur, Rue du Docteur Roux, Paris, France

“Study of human hepatotropic pathogens in mice with humanized live”

Building: Lwoff – Room: Retrovirus – Address: Institut Pasteur, Rue du Docteur Roux, Paris, France
2016-02-24 12:00:00 2016-02-24 13:00:00 Europe/Paris “Study of human hepatotropic pathogens in mice with humanized live” Philip MEULEMAN – Gent university, Department of Clinical chemistry, microbiology and immunology (Gent – Belgique) Contact : Sylvie GARCIA (sylvie.garcia@pasteur.fr – 89.92) Institut Pasteur, Rue du Docteur Roux, Paris, France

“Establishing a road map of the developmental program leading to infectivity in African trypanosomes”

Building: Lwoff – Room: Retrovirus – Address: Institut Pasteur, Rue du Docteur Roux, Paris, France
2016-03-17 12:00:00 2016-03-17 13:00:00 Europe/Paris “Establishing a road map of the developmental program leading to infectivity in African trypanosomes” Christian TSCHUDI – Yale University, School of Public Health (New Haven, USA) One of the fundamental steps in the life of a pathogen is the acquisition of infectivity. In the case of African trypanosomes, […] Institut Pasteur, Rue du Docteur Roux, Paris, France

“Coat replacement dynamics in the African trypanosome”

Building: Lwoff – Room: Retrovirus – Address: Institut Pasteur, Rue du Docteur Roux, Paris, France
2016-03-24 12:00:00 2016-03-24 14:00:00 Europe/Paris “Coat replacement dynamics in the African trypanosome” Nina PAPAVASILIOU – The Rockefeller University (New York – USA) The African trypanosome (T.brucei spp) is a unicellular parasite native to sub-Saharan Africa, and the causative agent of sleeping sickness in humans and of […] Institut Pasteur, Rue du Docteur Roux, Paris, France

“P.falciparum resistance to artemisinins: who cares?”

Building: Lwoff – Room: Retrovirus – Address: Institut Pasteur, Rue du Docteur Roux, Paris, France
2016-03-31 00:00:12 2016-03-31 13:00:00 Europe/Paris “P.falciparum resistance to artemisinins: who cares?” François NOSTEN – Mahidol Oxford University Research Unit, Shoklo Malaria Research Unit (Mae Sot – Thaïlande) There is an on-going debate in the malaria community as to whether artemisinin resistance in P.falciparum is really […] Institut Pasteur, Rue du Docteur Roux, Paris, France

“Insights into the B cell and Tfh cell biology underlying the inefficient acquisition of humoral immunity to malaria”

Building: Lwoff – Room: Retrovirus – Address: Institut Pasteur, Rue du Docteur Roux, Paris, France
2016-04-07 12:00:00 2016-04-07 14:00:00 Europe/Paris “Insights into the B cell and Tfh cell biology underlying the inefficient acquisition of humoral immunity to malaria” Peter CROMPTON – NIH, NIAID (Rockville – USA) Antibody responses to Plasmodium falciparum infection and candidate malaria vaccines are generally short-lived in children, leaving them susceptible to repeated bouts of febrile malaria. Long-lived antibody […] Institut Pasteur, Rue du Docteur Roux, Paris, France

Advancing scientific innovations with ECHO Acoustic Liquid Handling

Building: Lwoff – Room: RDC-14/15 – Address: Institut Pasteur, Paris, France
2016-04-15 09:30:00 2016-04-15 16:00:00 Europe/Paris Advancing scientific innovations with ECHO Acoustic Liquid Handling 9,45 – 10,30 : Acoustic Dispensing Usage for Drug Discovery in the CRUK Cancer Therapetics Unit. Dr Rosemary Burke, Senior Researcher Hit Discovery and Structural Design Team, CRUK London 10,45 – 11,30 : Single […] Institut Pasteur, Paris, France