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© Research
Publication : ACS infectious diseases

Zika Virus: Emergence, Phylogenetics, Challenges, and Opportunities

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in ACS infectious diseases - 12 Oct 2016

Rajah MM, Pardy RD, Condotta SA, Richer MJ, Sagan SM

Link to Pubmed [PMID] – 27704772

ACS Infect Dis 2016 11;2(11):763-772

Zika virus (ZIKV) is an emerging arthropod-borne pathogen that has recently gained notoriety due to its rapid and ongoing geographic expansion and its novel association with neurological complications. Reports of ZIKV-associated Guillain-Barré syndrome as well as fetal microcephaly place emphasis on the need to develop preventative measures and therapeutics to combat ZIKV infection. Thus, it is imperative that models to study ZIKV replication and pathogenesis and the immune response are developed in conjunction with integrated vector control strategies to mount an efficient response to the pandemic. This paper summarizes the current state of knowledge on ZIKV, including the clinical features, phylogenetic analyses, pathogenesis, and the immune response to infection. Potential challenges in developing diagnostic tools, treatment, and prevention strategies are also discussed.

https://www.ncbi.nlm.nih.gov/pubmed/27704772