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© Research
Publication : Scandinavian journal of immunology

VH-gene family dominance in ageing mice

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Scandinavian journal of immunology - 01 Feb 1994

Viale AC, Chies JA, Huetz F, Malenchere E, Weksler M, Freitas AA, Coutinho A

Link to Pubmed [PMID] – 8296161

Scand. J. Immunol. 1994 Feb;39(2):184-8

The cellular composition and VH-gene family repertoire were compared in different B-cell compartments from young adult (8-12 weeks) and old (18-24 months) C57BL/6 and BALB/c mice. Ageing mice were found to have a higher frequency of peripheral mature B cells utilizing genes from a single VH-gene family. While in each individual old C57BL/6 mice cells expressing the VH J558 gene family consistently were over-represented, a marked individual variation was observed in old BALB/c mice with increased frequency of either the VH J558, Q52 or J606 families. Aged mice were found also to have a reduced number of bone-marrow pre-B cells and an augmented number of splenic Ig-secreting cells. These results suggest that old mice express less diversified antibody repertoires possibly as a consequence of reduced input from precursors and increased peripheral selection, which may be responsible for the progressive establishment of immunodeficiency.

http://www.ncbi.nlm.nih.gov/pubmed/8296161