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© K. Melican.
Human microvessel (red) colonized by N. meningitidis (green).
Publication : Molecular biology of the cell

Vamp-7-dependent secretion at the immune synapse regulates antigen extraction and presentation in B-lymphocytes

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Molecular biology of the cell - 08 Feb 2017

Obino D, Diaz J, Sáez JJ, Ibañez-Vega J, Sáez PJ, Alamo M, Lankar D, Yuseff MI

Link to Pubmed [PMID] – 28179460

Mol. Biol. Cell 2017 Apr;28(7):890-897

Recognition of surface-tethered antigens (Ags) by B-cells leads to the formation of an immune synapse that promotes Ag uptake for presentation onto MHC-II molecules. Extraction of immobilized Ags at the immune synapse of B-cells relies on the local secretion of lysosomes, which are recruited to the Ag contact site by polarization of their microtubule network. Although conserved polarity proteins have been implicated in coordinating cytoskeleton remodeling with lysosome trafficking, the cellular machinery associated with lysosomal vesicles that regulates their docking and secretion at the synaptic interface has not been defined. Here we show that the v-SNARE protein Vamp-7 is associated with Lamp-1 lysosomal vesicles, which are recruited and docked at the center of the immune synapse of B-cells. A decrease in Vamp-7 expression does not alter lysosome transport to the synaptic interface but impairs their local secretion, a defect that compromises the ability of B-cells to extract, process, and present immobilized Ag. Thus our results reveal that B-cells rely on the SNARE protein Vamp-7 to promote the local exocytosis of lysosomes at the immune synapse, which is required for efficient Ag extraction and presentation.

https://www.ncbi.nlm.nih.gov/pubmed/28179460