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© Institut Pasteur
Corne d'Ammon (ou hippocampe) de renard atteint de rage sauvage. Coloration avec un conjugué fluorescent sur la nucléocapside du virus.
Publication : Science translational medicine

Vaccination of dogs in an African city interrupts rabies transmission and reduces human exposure

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Science translational medicine - 20 Dec 2017

Zinsstag J, Lechenne M, Laager M, Mindekem R, Naïssengar S, Oussiguéré A, Bidjeh K, Rives G, Tessier J, Madjaninan S, Ouagal M, Moto DD, Alfaroukh IO, Muthiani Y, Traoré A, Hattendorf J, Lepelletier A, Kergoat L, Bourhy H, Dacheux L, Stadler T, Chitnis N

Link to Pubmed [PMID] – 29263230

Sci Transl Med 2017 Dec;9(421)

Despite the existence of effective rabies vaccines for dogs, dog-transmitted human rabies persists and has reemerged in Africa. Two consecutive dog vaccination campaigns took place in Chad in 2012 and 2013 (coverage of 71% in both years) in the capital city of N’Djaména, as previously published. We developed a deterministic model of dog-human rabies transmission fitted to weekly incidence data of rabid dogs and exposed human cases in N’Djaména. Our analysis showed that the effective reproductive number, that is, the number of new dogs infected by a rabid dog, fell to below one through November 2014. The modeled incidence of human rabies exposure fell to less than one person per million people per year. A phylodynamic estimation of the effective reproductive number from 29 canine rabies virus genetic sequences of the viral N-protein confirmed the results of the deterministic transmission model, implying that rabies transmission between dogs was interrupted for 9 months. However, new dog rabies cases appeared earlier than the transmission and phylodynamic models predicted. This may have been due to the continuous movement of rabies-exposed dogs into N’Djaména from outside the city. Our results show that canine rabies transmission to humans can be interrupted in an African city with currently available dog rabies vaccines, provided that the vaccination area includes larger adjacent regions, and local communities are informed and engaged.

https://www.ncbi.nlm.nih.gov/pubmed/29263230