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© Research
Publication : Microbial pathogenesis

Ultrastructural analysis of the interactions between Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica and human tracheal epithelial cells

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Microbial pathogenesis - 01 Jan 2005

Gueirard P, Bassinet L, Bonne I, Prevost MC, Guiso N

Link to Pubmed [PMID] – 15652294

Microb. Pathog. 2005 Jan;38(1):41-6

Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica are respiratory pathogens that colonize the respiratory tract of their host after adhesion to the respiratory epithelium. Presently, the intracellular fate of these bacteria in human tracheal epithelial cells was compared by use of transmission electron microscopy. The three species, even when cytotoxic, were taken-up by epithelial cells. Although, some intracellular bacteria appeared morphologically intact and survived a few days inside epithelial cells, most of them appeared quickly degraded, phenomenon which was associated with an intense cell metabolic activity. Even cytotoxic Bordetella species is ultimately killed by human epithelial cells.

http://www.ncbi.nlm.nih.gov/pubmed/15652294