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© Research
Publication : BMC genomics

Transcriptional signatures of BALB/c mouse macrophages housing multiplying Leishmania amazonensis amastigotes

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in BMC genomics - 20 Mar 2009

Osorio y Fortéa J, de La Llave E, Regnault B, Coppée JY, Milon G, Lang T, Prina E

Link to Pubmed [PMID] – 19302708

BMC Genomics 2009;10:119

Mammal macrophages (MPhi) display a wide range of functions which contribute to surveying and maintaining tissue integrity. One such function is phagocytosis, a process known to be subverted by parasites like Leishmania (L). Indeed, the intracellular development of L. amazonensis amastigote relies on the biogenesis and dynamic remodelling of a phagolysosome, termed the parasitophorous vacuole, primarily within dermal MPhi.

http://www.ncbi.nlm.nih.gov/pubmed/19302708