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© Research
Publication : Nucleic acids research

Transcription and nuclear transport of CAG/CTG trinucleotide repeats in yeast

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nucleic acids research - 15 Aug 2002

Fabre E, Dujon B, Richard GF

Link to Pubmed [PMID] – 12177295

Nucleic Acids Res. 2002 Aug;30(16):3540-7

Trinucleotide repeats are involved in several neurological disorders in humans. DNA sequences containing CAG/CTG repeats are prone to slippage during replication and double-strand break repair. The effects of trinucleotide repeats on transcription and on nuclear export were analyzed in vivo in yeast. Transcription of a CAG/CTG trinucleotide repeat in the 3′-untranslated region of a URA3 reporter gene leads to transcription of messenger RNAs several kilobases longer than the expected size. These long mRNAs form more readily when CAG rather than CTG repeats are transcribed. CAG- or CUG-containing transcripts show a non-homogeneous cellular localization. We propose that long mRNAs result from transcription slippage, and discuss the possible implications for human diseases.

http://www.ncbi.nlm.nih.gov/pubmed/12177295