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© Michel-Robert Popoff
Clostridium difficile en microscopie à contraste de phase. On distingue des bactéries sporulées, non sporulées et d'autres en cours de lyse (destruction). Bactérie de l'environnement (sol, eau, foin, sable), elle est à l'origine d'infections nosocomiales survenant après un traitement antibiotique : Clostridium difficile prédomine alors que les autres bactéries de la flore intestinale ont été détruites. L'infection peut provoquer deux types de pathologies graves : les colites pseudo-membraneuses dont l'origine est quasiment due à 100 % à C. difficile et la diarrhée post-antibiothérapie due à C. difficile dans 30 % des cas de ces diarrhées.
Publication : Journal of bacteriology

Three different systems participate in L-cystine uptake in Bacillus subtilis

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of bacteriology - 01 Aug 2004

Burguière P, Auger S, Hullo MF, Danchin A, Martin-Verstraete I

Link to Pubmed [PMID] – 15262924

J. Bacteriol. 2004 Aug;186(15):4875-84

The symporter YhcL and two ATP binding cassette transporters, YtmJKLMN and YckKJI, were shown to mediate L-cystine uptake in Bacillus subtilis. A triple DeltayhcL DeltaytmJKLMN DeltayckK mutant was unable to grow in the presence of L-cystine and to take up L-cystine. We propose that yhcL, ytmJKLMN, and yckKJI should be renamed tcyP, tcyJKLMN, and tcyABC, respectively. The L-cystine uptake by YhcL (K(m) = 0.6 microM) was strongly inhibited by seleno-DL-cystine, while the transport due to the YtmJKLMN system (K(m) = 2.5 microM) also drastically decreased in the presence of DL-cystathionine, L-djenkolic acid, or S-methyl-L-cysteine. Accordingly, a DeltaytmJKLMN mutant did not grow in the presence of 100 microM DL-cystathionine, 100 microM L-djenkolic acid, or 100 microM S-methyl-L-cysteine. The expression of the ytmI operon and the yhcL gene was regulated in response to sulfur availability, while the level of expression of the yckK gene remained low under all the conditions tested.

http://www.ncbi.nlm.nih.gov/pubmed/15262924