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© Mart Krupovic, Junfeng Liu
Scanning electron micrograph of Saccharolobus islandicus cells (light blue) infected with the lemon-shaped virus STSV2 (yellow). Artistic rendering by Ala Krupovic.
Publication : BMC biology

The replication machinery of LUCA: common origin of DNA replication and transcription

Team: Archaeal Virology
Member: Mart Krupovic
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in BMC biology - 09 Jun 2020

Koonin EV, Krupovic M, Ishino S, Ishino Y

Link to Pubmed [PMID] – 32517760

Link to DOI – 10.1186/s12915-020-00800-9

BMC Biol. 2020 Jun; 18(1): 61

Origin of DNA replication is an enigma because the replicative DNA polymerases (DNAPs) are not homologous among the three domains of life, Bacteria, Archaea, and Eukarya. The homology between the archaeal replicative DNAP (PolD) and the large subunits of the universal RNA polymerase (RNAP) responsible for transcription suggests a parsimonious evolutionary scenario. Under this model, RNAPs and replicative DNAPs evolved from a common ancestor that functioned as an RNA-dependent RNA polymerase in the RNA-protein world that predated the advent of DNA replication. The replicative DNAP of the Last Universal Cellular Ancestor (LUCA) would be the ancestor of the archaeal PolD.