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© Research
Publication : PloS one

The Panhandle formed by influenza A and C virus NS non-coding regions determines NS segment expression

Team: Archived: Molecular Genetics of RNA Viruses
Member: Sylvie van Der Werf
Member:
Member: Bernadette Crescenzo
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in PloS one - 21 Nov 2013

Crescenzo-Chaigne B, Barbezange C, van der Werf S

Link to Pubmed [PMID] – 24348921

PLoS ONE 2013;8(11):e81550

Exchange of the extremities of the NS segment of type A and C influenza viruses in reverse genetics systems was used to assess their putative role in type specificity. Restoration of each specific proximal panhandle was mandatory to allow the rescue of viruses with heterotypic extremities. Moreover, the transcription level of the modified segment seemed to be directly affected by the distal panhandle strength.