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© Research
Publication : PLoS pathogens

The epigenetic regulator G9a mediates tolerance to RNA virus infection in Drosophila.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in PLoS pathogens - 01 Apr 2015

Merkling SH, Bronkhorst AW, Kramer JM, Overheul GJ, Schenck A, Van Rij RP,

Link to Pubmed [PMID] – 25880195

Link to DOI – 10.1371/journal.ppat.1004692

PLoS Pathog 2015 Apr; 11(4): e1004692

Little is known about the tolerance mechanisms that reduce the negative effects of microbial infection on host fitness. Here, we demonstrate that the histone H3 lysine 9 methyltransferase G9a regulates tolerance to virus infection by shaping the response of the evolutionary conserved Jak-Stat pathway in Drosophila. G9a-deficient mutants are more sensitive to RNA virus infection and succumb faster to infection than wild-type controls, which was associated with strongly increased Jak-Stat dependent responses, but not with major differences in viral load. Genetic experiments indicate that hyperactivated Jak-Stat responses are associated with early lethality in virus-infected flies. Our results identify an essential epigenetic mechanism underlying tolerance to virus infection.

https://pubmed.ncbi.nlm.nih.gov/25880195