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© Institut Pasteur
Macrophages et lymphocytes de souris. Image colorisée.
Publication : Nature reviews. Immunology

T(H)1 cells control themselves by producing interleukin-10

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature reviews. Immunology - 01 Jun 2007

O'Garra A, Vieira P

Link to Pubmed [PMID] – 17525751

Nat. Rev. Immunol. 2007 Jun;7(6):425-8

Inflammatory T helper 1 (T(H)1)-cell responses successfully eradicate pathogens, but often also cause immunopathology. To minimize this deleterious side-effect the anti-inflammatory cytokine interleukin-10 (IL-10) is produced. Although IL-10 was originally isolated from T(H)2 cells it is now known to be produced by many cell types. Here, we discuss the recent evidence that shows that T(H)1 cells are the main source of IL-10 that controls the immune response against Leishmania major and Toxoplasma gondii infection.

http://www.ncbi.nlm.nih.gov/pubmed/17525751