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© Research
Publication : Current topics in microbiology and immunology

SUMO, the three Rs and cancer

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current topics in microbiology and immunology - 01 Jan 2007

Seeler JS, Bischof O, Nacerddine K, Dejean A

Link to Pubmed [PMID] – 17217038

Curr. Top. Microbiol. Immunol. 2007;313:49-71

SUMO modification (sumoylation) plays important roles in nucleo-cytoplasmic transport, maintenance of sub-nuclear architecture, the regulation of gene expression and in DNA replication, repair and recombination. Here we review recent evidence for SUMO’s role in protecting genomic integrity at both the chromosomal and the DNA level. Furthermore, the involvement of sumoylation and of specific SUMO targets in cancer is discussed.

http://www.ncbi.nlm.nih.gov/pubmed/17217038