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© Thierry Blisnick & Philippe Bastin, Institut Pasteur
Bloodstream Trypanosoma brucei cell
Publication : Current opinion in microbiology

Rodent malaria models: insights into human disease and parasite biology.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in microbiology - 01 Dec 2018

De Niz M, Heussler VT,

Link to Pubmed [PMID] – 30317152

Link to DOI – S1369-5274(17)30250-310.1016/j.mib.2018.09.003

Curr Opin Microbiol 2018 12; 46(): 93-101

The use of rodents as model organisms to study human disease is based on the genetic and physiological similarities between the species. Successful molecular methods to generate transgenic reporter or humanized rodents has rendered rodents as powerful tools for understanding biological processes and host-pathogen interactions relevant to humans. In malaria research, rodent models have been pivotal for the study of liver stages, syndromes arising from blood stages of infection, and malaria transmission to and from the mammalian host. Importantly, many in vivo findings are comparable to pathology observed in humans only when adequate combinations of rodent strains and Plasmodium parasites are used.

https://pubmed.ncbi.nlm.nih.gov/30317152