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© Research
Publication : Nature communications

Rapid decline of neutralizing antibodies against SARS-CoV-2 among infected healthcare workers.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature communications - 08 Feb 2021

Marot S, Malet I, Leducq V, Zafilaza K, Sterlin D, Planas D, Gothland A, Jary A, Dorgham K, Bruel T, , Burrel S, Boutolleau D, Schwartz O, Gorochov G, Calvez V, Marcelin AG,

Link to Pubmed [PMID] – 33558507

Link to DOI – 10.1038/s41467-021-21111-9

Nat Commun 2021 02; 12(1): 844

There are only few data concerning persistence of neutralizing antibodies (NAbs) among SARS-CoV-2-infected healthcare workers (HCW). These individuals are particularly exposed to SARS-CoV-2 infection and at potential risk of reinfection. We followed 26 HCW with mild COVID-19 three weeks (D21), two months (M2) and three months (M3) after the onset of symptoms. All the HCW had anti-receptor binding domain (RBD) IgA at D21, decreasing to 38.5% at M3 (p < 0.0001). Concomitantly a significant decrease in NAb titers was observed between D21 and M2 (p = 0.03) and between D21 and M3 (p < 0.0001). Here, we report that SARS-CoV-2 can elicit a NAb response correlated with anti-RBD antibody levels. However, this neutralizing activity declines, and may even be lost, in association with a decrease in systemic IgA antibody levels, from two months after disease onset. This short-lasting humoral protection supports strong recommendations to maintain infection prevention and control measures in HCW, and suggests that periodic boosts of SARS-CoV-2 vaccination may be required.

https://pubmed.ncbi.nlm.nih.gov/33558507