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© Research
Publication : The Journal of neuroscience : the official journal of the Society for Neuroscience

Properties of piriform cortex pyramidal cell dendrites: implications for olfactory circuit design.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of neuroscience : the official journal of the Society for Neuroscience - 07 Oct 2009

Bathellier B, Margrie TW, Larkum ME,

Link to Pubmed [PMID] – 19812339

Link to DOI – 10.1523/JNEUROSCI.1124-09.2009

J Neurosci 2009 Oct; 29(40): 12641-52

Unlike the neocortex, sensory input to the piriform cortex is anatomically segregated in layer 1, making it ideal for studying the dendritic integration of synaptic inputs pivotal for sensory information processing. Here we investigated dendritic integration of olfactory bulb inputs in pyramidal cells using dual patch-clamp recordings along the soma-apical dendritic axis. We found that these dendrites are relatively compact with 50% maximal somatic current loss for synaptic inputs arriving at distal dendritic regions. Distal dendrites could generate small and fast local spikes, but they had little impact on the soma, indicating that they are only weakly active. In contrast to the neocortex, we found no evidence for dendritic Ca(2+) or NMDA spikes though these dendrites actively supported action potential backpropagation with concomitant entry of Ca(2+) ions. Based on experiments and simulations we suggest that regardless of dendritic location, olfactory bulb inputs have nearly uniform potency and are distributed diffusely over the distal apical tree (layer Ia), thereby minimizing sublinear summation effects. This indicates that any stimulus feature extraction performed by these cells will occur at the soma and is based on the nearly linear sum of olfactory bulb inputs, rather than on explicitly designed clusters of functionally related synapses in the dendritic tree.

https://pubmed.ncbi.nlm.nih.gov/19812339