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© Pierre Lafaye
Astrocytes marqués par des anticorps VHH anti-GFAP. Des anticorps d'alpagas dirigés contre une protéine spécifique des astrocytes, la GFAP (Glial Fibrillary Acidic Protein), ont été obtenus à partir de camélidés immunisés. La partie VHH (partie de l'anticorps qui reconnaît l'antigène) a été exprimée sous forme recombinante chez Escherichia coli.
Publication : The European journal of medicine

Production and characterization of monoclonal antibodies to human Pneumocystis carinii for the diagnosis of P. carinii pneumonia

Team: Antibody Engineering
Member: Farida Nato
Member: Pierre Lafaye
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The European journal of medicine - 01 Jun 1992

Nato F, Contini C, Zamora-Zavala C, Viscardi P, Delia S, Mojon M, Mazie JC

Link to Pubmed [PMID] – 1341432

Eur J Med 1992 Jun;1(3):132-8

Monoclonal antibodies against human Pneumocystis carinii were produced by fusion of myeloma cells (X63-AG8.653) with splenocytes from Biozzi mice that had been immunized against P. carinii cysts isolated from infected human lung. The aim of this study was to evaluate the usefulness of these monoclonal antibodies for the diagnosis of P. carinii pneumonia by indirect immunofluorescence in comparison with a modified silver stain method and commercial kits.

http://www.ncbi.nlm.nih.gov/pubmed/1341432