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© Thierry Blisnick & Philippe Bastin, Institut Pasteur
Bloodstream Trypanosoma brucei cell
Publication : Wellcome open research

Probing Plasmodium falciparum sexual commitment at the single-cell level.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Wellcome open research - 01 Jan 2018

Brancucci NMB, De Niz M, Straub TJ, Ravel D, Sollelis L, Birren BW, Voss TS, Neafsey DE, Marti M,

Link to Pubmed [PMID] – 30320226

Link to DOI – 10.12688/wellcomeopenres.14645.4

Wellcome Open Res 2018 ; 3(): 70

Background: Malaria parasites go through major transitions during their complex life cycle, yet the underlying differentiation pathways remain obscure. Here we apply single cell transcriptomics to unravel the program inducing sexual differentiation in Plasmodium falciparum. Parasites have to make this essential life-cycle decision in preparation for human-to-mosquito transmission. Methods: By combining transcriptional profiling with quantitative imaging and genetics, we defined a transcriptional signature in sexually committed cells. Results: We found this transcriptional signature to be distinct from general changes in parasite metabolism that can be observed in response to commitment-inducing conditions. Conclusions: This proof-of-concept study provides a template to capture transcriptional diversity in parasite populations containing complex mixtures of different life-cycle stages and developmental programs, with important implications for our understanding of parasite biology and the ongoing malaria elimination campaign.

https://pubmed.ncbi.nlm.nih.gov/30320226