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© Research
Publication : Immunology letters

Potential deleterious effect of anti-viral cytotoxic lymphocyte through the CD95 (FAS/APO-1)-mediated pathway during chronic HIV infection

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Immunology letters - 01 Jun 1997

Garcia S, Fevrier M, Dadaglio G, Lecoeur H, Riviere Y, Gougeon ML

Link to Pubmed [PMID] – 9232425

Immunol. Lett. 1997 Jun;57(1-3):53-8

The potential deleterious effect through a CD95-based pathway of anti-viral cytotoxic lymphocyte (CTL) during HIV-infection was studied. The present paper reports that a Nef specific CTL line derived from an HIV-infected person is able to kill not only Nef-expressing target cells but also CD95+ compliant Jurkat cells. The two mechanisms of cytotoxicity, i.e. perforin-vs-CD95-dependent were differentiated according to their respective Ca(2+)-dependence. The existence of the dual killing machinery in the anti-HIV CTL line was correlated with the coexpression in these cells of perforin and CD95-L molecules. A model of AIDS pathogenesis involving the deleterious effect through the CD95 pathway of the viral specific CTL response is discussed.

http://www.ncbi.nlm.nih.gov/pubmed/9232425