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© Research
Publication : BMC genetics

Polymeric immunoglobulin receptor polymorphisms and risk of nasopharyngeal cancer

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in BMC genetics - 21 Jan 2003

Hirunsatit R, Kongruttanachok N, Shotelersuk K, Supiyaphun P, Voravud N, Sakuntabhai A, Mutirangura A

Link to Pubmed [PMID] – 12546713

BMC Genet. 2003 Jan;4:3

Epstein-Barr virus (EBV) associated nasopharyngeal cancer (NPC) is an important squamous cell cancer endemic in Southeast Asia and the Far East and can be considered a multifactorial genetic disease. This research explores potential associations between nasopharyngeal epithelial EBV receptor and NPC susceptibility. To prove the hypothesis, we evaluated two candidate genes, complement receptor 2 (CR2) and polymeric immunoglobulin receptor (PIGR) by using 4 SNPs, CR2IVS2-848C–>T, PIGRIVS3-156G–>T, PIGR1093G–>A and PIGR1739C–>T, to genotype 175 cases and 317 controls, divided into Thai, Chinese and Thai-Chinese based on their respective ethnic origins.

http://www.ncbi.nlm.nih.gov/pubmed/12546713