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© K. Melican.
Human microvessel (red) colonized by N. meningitidis (green).
Publication : Molecular biology of the cell

Polarity protein Par3 controls B-cell receptor dynamics and antigen extraction at the immune synapse

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Molecular biology of the cell - 28 Jan 2015

Reversat A, Yuseff MI, Lankar D, Malbec O, Obino D, Maurin M, Penmatcha NV, Amoroso A, Sengmanivong L, Gundersen GG, Mellman I, Darchen F, Desnos C, Pierobon P, Lennon-Duménil AM

Link to Pubmed [PMID] – 25631815

Mol. Biol. Cell 2015 Apr;26(7):1273-85

B-cell receptor (BCR) engagement with surface-tethered antigens leads to the formation of an immune synapse, which facilitates antigen uptake for presentation to T-lymphocytes. Antigen internalization and processing rely on the early dynein-dependent transport of BCR-antigen microclusters to the synapse center, as well as on the later polarization of the microtubule-organizing center (MTOC). MTOC repositioning allows the release of proteases and the delivery of MHC class II molecules at the synapse. Whether and how these events are coordinated have not been addressed. Here we show that the ancestral polarity protein Par3 promotes BCR-antigen microcluster gathering, as well as MTOC polarization and lysosome exocytosis, at the synapse by facilitating local dynein recruitment. Par3 is also required for antigen presentation to T-lymphocytes. Par3 therefore emerges as a key molecule in the coupling of the early and late events needed for efficient extraction and processing of immobilized antigen by B-cells.

https://www.ncbi.nlm.nih.gov/pubmed/25631815