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© Research
Publication : The European journal of neuroscience

Novelty enhances retrieval: molecular mechanisms involved in rat hippocampus

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The European journal of neuroscience - 01 Apr 2001

Izquierdo LA, Viola H, Barros DM, Alonso M, Vianna MR, Furman M, Levi de Stein M, Szapiro G, Rodrigues C, Choi H, Medina JH, Izquierdo I

Link to Pubmed [PMID] – 11298809

Eur. J. Neurosci. 2001 Apr;13(7):1464-7

Rats exposed to a novel environment just prior to or 1-2 h, but not 4 or 6 h, before retention testing exhibited an enhanced retrieval of a one-trial inhibitory avoidance training. The bilateral intrahippocampal infusion of PD098059, an inhibitor of mitogen-activated protein kinase (MAPK), the specific upstream activator of p42 and p44 MAPKs, given 10 min before the exposure to the novel environment, blocked the enhancing effect of novelty on memory retrieval. In addition, prenovelty infusion of DL-2-amino-5-phosphonovalerate (APV), an antagonist of glutamate NMDA receptors, produced similar effects. The exposure to the novel environment is associated with an activation of p42 and p44 MAPKs and an increase in the phosphorylation state of the transcription factor cAMP response element binding protein (CREB). No changes were observed in cAMP-dependent protein kinase (PKA) activity or in alpha-CAMKII activation. Taken together, our results indicate that novelty activates hippocampal MAPKs, which are necessary, along with glutamate NMDA receptors, for the enhancing effect of novelty on retrieval.

http://www.ncbi.nlm.nih.gov/pubmed/11298809