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© Pierre Lafaye
Astrocytes marqués par des anticorps VHH anti-GFAP. Des anticorps d'alpagas dirigés contre une protéine spécifique des astrocytes, la GFAP (Glial Fibrillary Acidic Protein), ont été obtenus à partir de camélidés immunisés. La partie VHH (partie de l'anticorps qui reconnaît l'antigène) a été exprimée sous forme recombinante chez Escherichia coli.
Publication : PLoS medicine

New rapid diagnostic tests for Neisseria meningitidis serogroups A, W135, C, and Y

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in PLoS medicine - 01 Sep 2006

Chanteau S, Dartevelle S, Mahamane AE, Djibo S, Boisier P, Nato F

Link to Pubmed [PMID] – 16953658

PLoS Med. 2006 Sep;3(9):e337

Outbreaks of meningococcal meningitis (meningitis caused by Neisseria meningitidis) are a major public health concern in the African “meningitis belt,” which includes 21 countries from Senegal to Ethiopia. Of the several species that can cause meningitis, N. meningitidis is the most important cause of epidemics in this region. In choosing the appropriate vaccine, accurate N. meningitidis serogroup determination is key. To this end, we developed and evaluated two duplex rapid diagnostic tests (RDTs) for detecting N. meningitidis polysaccharide (PS) antigens of several important serogroups.

http://www.ncbi.nlm.nih.gov/pubmed/16953658