Link to Pubmed [PMID] – 20846863
Bioorg. Med. Chem. Lett. 2010 Nov;20(21):6213-6
In this Letter we describe the design, synthesis, screening, and optimization of a new family of ADAMTS-5 inhibitors. These inhibitors display an original 1,2,4-triazole-3-thiol scaffold as a putative zinc binding-group. In vitro results are rationalized by in silico docking of the compounds in ADAMTS-5’s crystal structure.