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© Emeline Camand
Marquage par immunofluorescence d'astrocytes tumoraux ou astrocytomes (lignée cellulaire humaine U373), montrant en rouge, APC et en vert, la tubuline des microtubules. APC est un supresseur de tumeur qui est impliqué dans la polarisation des astrocytes normaux. La localisation d'APC est altérée dans des lignées de gliomes. Pour essayer de corriger, les dérèglements observés lors de la migration des cellules d'astrocytes tumuraux ou gliomes on cherche à connaitre les mécanismes moléculaires fondamentaux qui controlent la polarisation et la migration cellulaire.
Publication : Current opinion in cell biology

Neighborly relations during collective migration

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in cell biology - 03 Jul 2014

Etienne-Manneville S

Link to Pubmed [PMID] – 24997300

Curr. Opin. Cell Biol. 2014 Oct;30:51-9

The collective migration of sheets, cohorts, chains or streams of cells contributes to embryogenesis, tissue remodeling and repair as well as to cancer invasion. The functional coordination between neighboring cells is at the heart of collective migration, during which cells migrate with a similar speed in an identical direction. Far from being the result of the simultaneous migration of isolated cells, collective migration relies on the intercellular communication between migrating cells. Although the mechanisms of cell coordination are far from being completely understood, accumulated evidence show that exchange of mechanical and chemical information by direct intercellular contacts and by soluble extracellular signals orchestrate the coordinated behavior of collectively migrating cells.

http://www.ncbi.nlm.nih.gov/pubmed/24997300