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© Research
Publication : Nature communications

Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature communications - 09 Feb 2017

Smith N, Pietrancosta N, Davidson S, Dutrieux J, Chauveau L, Cutolo P, Dy M, Scott-Algara D, Manoury B, Zirafi O, McCort-Tranchepain I, Durroux T, Bachelerie F, Schwartz O, Münch J, Wack A, Nisole S, Herbeuval JP

Link to Pubmed [PMID] – 28181493

Nat Commun 2017 02;8:14253

Plasmacytoid dendritic cells (pDC) are specialized in secretion of type I interferon in response to pathogens. Here we show that natural monoamines and synthetic amines inhibit pDC activation by RNA viruses. Furthermore, a synthetic analogue of histamine reduces type I interferon production in a mouse model of influenza infection. We identify CXC chemokine receptor 4 (CXCR4) as a receptor used by amines to inhibit pDC. Our study establishes a functional link between natural amines and the innate immune system and identifies CXCR4 as a potential ‘on-off’ switch of pDC activity with therapeutic potential.

https://www.ncbi.nlm.nih.gov/pubmed/28181493