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© Institut Pasteur
Cryptococcus neoformans
Publication : Proceedings of the National Academy of Sciences of the United States of America

Monosomy of a specific chromosome determines L-sorbose utilization: a novel regulatory mechanism in Candida albicans

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Proceedings of the National Academy of Sciences of the United States of America - 28 Apr 1998

Janbon G, Sherman F, Rustchenko E

Link to Pubmed [PMID] – 9560244

Proc. Natl. Acad. Sci. U.S.A. 1998 Apr;95(9):5150-5

We report the identification of the gene, SOU1, required for L-sorbose assimilation in Candida albicans. The level of the expression of SOU1 is determined by the copy number of chromosome III (also denoted chromosome 5), such that monosomic strains assimilate L-sorbose, whereas disomic strains do not, in spite of the fact that SOU1 is not on this chromosome. We suggest that C. albicans contains a resource of potentially beneficial genes that are activated by changes in chromosome number, and that this elaborate mechanism regulates the utilization of food supplies and possibly other important functions, thus representing a novel general means for regulating gene expression in microbes.

http://www.ncbi.nlm.nih.gov/pubmed/9560244