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© Nicola Festuccia, Institut Pasteur
Mouse embryonic stem cells stained for Ki67 (red) and Esrrb (green)
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in cell biology - 13 Jan 2021

Gonzalez I, Molliex A, Navarro P,

Link to Pubmed [PMID] – 33454629

Link to DOI – S0955-0674(20)30174-510.1016/j.ceb.2020.12.009

Curr Opin Cell Biol 2021 Jan; 69(): 41-47

When cells enter mitosis, they undergo series of dramatic changes in their structure and function that severely hamper gene regulatory processes and gene transcription. This raises the question of how daughter cells efficiently recapitulate the gene expression profile of their mother such that cell identity can be preserved. Here, we review recent evidence supporting the view that distinct chromatin-associated mechanisms of gene-regulatory inheritance assist daughter cells in the postmitotic reestablishment of gene activity with increased fidelity.

https://pubmed.ncbi.nlm.nih.gov/33454629