Link to Pubmed [PMID] – 33454629
Link to DOI – S0955-0674(20)30174-510.1016/j.ceb.2020.12.009
Curr Opin Cell Biol 2021 Jan; 69(): 41-47
When cells enter mitosis, they undergo series of dramatic changes in their structure and function that severely hamper gene regulatory processes and gene transcription. This raises the question of how daughter cells efficiently recapitulate the gene expression profile of their mother such that cell identity can be preserved. Here, we review recent evidence supporting the view that distinct chromatin-associated mechanisms of gene-regulatory inheritance assist daughter cells in the postmitotic reestablishment of gene activity with increased fidelity.