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© Marion Coolen
Radial glia neural stem cells of the adult zebrafish telencephalon electroporated with a membrane tagged GFP
Publication : Frontiers in cellular neuroscience

miR-9: a versatile regulator of neurogenesis

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Frontiers in cellular neuroscience - 20 Nov 2013

Coolen M, Katz S, Bally-Cuif L

Link to Pubmed [PMID] – 24312010

Front Cell Neurosci 2013;7:220

Soon after its discovery, microRNA-9 (miR-9) attracted the attention of neurobiologists, since it is one of the most highly expressed microRNAs in the developing and adult vertebrate brain. Functional analyses in different vertebrate species have revealed a prominent role of this microRNA in balancing proliferation in embryonic neural progenitor populations. Key transcriptional regulators such as FoxG1, Hes1 or Tlx, were identified as direct targets of miR-9, placing it at the core of the gene network controlling the progenitor state. Recent data also suggest that this function could extend to adult neural stem cells. Other studies point to a role of miR-9 in differentiated neurons. Moreover miR-9 has been implicated in human brain pathologies, either displaying a protective role, such as in Progeria, or participating in disease progression in brain cancers. Altogether functional studies highlight a prominent feature of this highly conserved microRNA, its functional versatility, both along its evolutionary history and across cellular contexts.

http://www.ncbi.nlm.nih.gov/pubmed/24312010