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© Research
Publication : PLoS neglected tropical diseases

Midgut barriers prevent the replication and dissemination of the yellow fever vaccine in Aedes aegypti

Team: Group : Flavivirus pathogenesis
Team: Innovation lab : vaccines
Member: Guillaume Beauclair
Member: Nolwenn Jouvenet
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in PLoS neglected tropical diseases - 14 Aug 2019

Danet L, Beauclair G, Berthet M, Moratorio G, Gracias S, Tangy F, Choumet V, Jouvenet N

Link to Pubmed [PMID] – 31412040

PLoS Negl Trop Dis 2019 08;13(8):e0007299

To be transmitted to vertebrate hosts via the saliva of their vectors, arthropod-borne viruses have to cross several barriers in the mosquito body, including the midgut infection and escape barriers. Yellow fever virus (YFV) belongs to the genus Flavivirus, which includes human viruses transmitted by Aedes mosquitoes, such as dengue and Zika viruses. The live-attenuated YFV-17D vaccine has been used safely and efficiently on a large scale since the end of World War II. Early studies have shown, using viral titration from salivary glands of infected mosquitoes, that YFV-17D can infect Aedes aegypti midgut, but does not disseminate to other tissues.

https://www.ncbi.nlm.nih.gov/pubmed/31412040