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© Research
Publication : IUBMB life

MicroRNAs and lncRNAs in senescence: A re-view

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in IUBMB life - 19 May 2015

Bischof O, Martínez-Zamudio RI

Link to Pubmed [PMID] – 25990945

IUBMB Life 2015 Apr;67(4):255-67

Cellular senescence is a stress response to a variety of extrinsic and intrinsic insults that cause genomic or epigenomic perturbations. It is now widely recognized as a potent tumor suppressor mechanism as well as a biological process impacting aging and organismal development. Like other cell fate decisions, senescence is executed and maintained by an intricate network of transcription factors (TFs), chromatin modifiers, and noncoding RNAs (ncRNAs). Altogether, these factors cooperate to implement the gene expression program that initiates and sustains the senescent phenotype. In the context of senescence, microRNAs (miRs) and long ncRNAs have been found to play regulatory roles at both the transcriptional and post-transcriptional levels. In this review, we discuss recent developments in the field and point toward future research directions to gain a better understanding of ncRNAs in senescence.

http://www.ncbi.nlm.nih.gov/pubmed/25990945