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© Research
Publication : Current opinion in microbiology

Mechanisms of genome evolution in Candida albicans

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in microbiology - 01 Jan 2019

Ene IV, Bennett RJ, Anderson MZ

Link to Pubmed [PMID] – 31176092

Link to DOI – S1369-5274(18)30092-410.1016/j.mib.2019.05.001

Curr Opin Microbiol 2019 12; 52(): 47-54

The fungus Candida albicans exists as a prevalent commensal and an important opportunistic pathogen that can infect multiple niches of its human host. Recent studies have examined the diploid genome of C. albicans by performing both short-term microevolution studies and comparative genomics on collections of clinical isolates. Common mechanisms driving genome dynamics include accumulation of point mutations, loss of heterozygosity (LOH) events, large-scale chromosomal rearrangements, and even ploidy change, with important consequences for both drug resistance and host adaptation. Evidence for recombination between C. albicans lineages also highlights a role for (para)sex in shaping the species population structure. Ongoing work will continue to define the contributions of genome evolution to phenotypic variation and the role of host pressures in driving adaptive processes.

https://pubmed.ncbi.nlm.nih.gov/31176092