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© Research
Publication : Nature Microbiology

Mechanical strain-sensing implicated in cell shape recovery in Escherichia coli

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature Microbiology - 24 Jul 2017

Wong F, Renner LD, Özbaykal G, Paulose J, Weibel DB, van Teeffelen S, Amir A

Link to Pubmed [PMID] – 28737752

Nat. Microbio. 2017; 2:17115

The shapes of most bacteria are imparted by the structures of their peptidoglycan cell walls, which are determined by many dynamic processes that can be described on various length scales ranging from short-range glycan insertions to cellular- scale elasticity. Understanding the mechanisms that main- tain stable, rod-like morphologies in certain bacteria has proved to be challenging due to an incomplete understanding of the feedback between growth and the elastic and geometric properties of the cell wall. Here, we probe the effects of mechanical strain on cell shape by modelling the mechanical strains caused by bending and differential growth of the cell wall. We show that the spatial coupling of growth to regions of high mechanical strain can explain the plastic response of cells to bending and quantitatively predict the rate at which bent cells straighten. By growing filamentous Escherichia coli cells in doughnut-shaped microchambers, we find that the cells recovered their straight, native rod-shaped morphologies when released from captivity at a rate consistent with the theoretical prediction. We then measure the localization of MreB, an actin homologue crucial to cell wall synthesis, inside confinement and during the straightening process, and find that it cannot explain the plastic response to bending or the observed straightening rate. Our results implicate mechan- ical strain sensing, implemented by components of the elonga- some yet to be fully characterized, as an important component of robust shape regulation in E. coli.

https://www.nature.com/articles/nmicrobiol2017115