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© Research
Publication : Science advances

Mapping the structure and biological functions within mesenchymal bodies using microfluidics.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Science advances - 04 Mar 2020

Sart S, Tomasi RF, Barizien A, Amselem G, Cumano A, Baroud CN,

Link to Pubmed [PMID] – 32181333

Link to DOI [DOI] – 10.1126/sciadv.aaw7853

Sci Adv 2020 03; 6(10): eaaw7853

Organoids that recapitulate the functional hallmarks of anatomic structures comprise cell populations able to self-organize cohesively in 3D. However, the rules underlying organoid formation in vitro remain poorly understood because a correlative analysis of individual cell fate and spatial organization has been challenging. Here, we use a novel microfluidics platform to investigate the mechanisms determining the formation of organoids by human mesenchymal stromal cells that recapitulate the early steps of condensation initiating bone repair in vivo. We find that heterogeneous mesenchymal stromal cells self-organize in 3D in a developmentally hierarchical manner. We demonstrate a link between structural organization and local regulation of specific molecular signaling pathways such as NF-κB and actin polymerization, which modulate osteo-endocrine functions. This study emphasizes the importance of resolving spatial heterogeneities within cellular aggregates to link organization and functional properties, enabling a better understanding of the mechanisms controlling organoid formation, relevant to organogenesis and tissue repair.

https://pubmed.ncbi.nlm.nih.gov/32181333