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© Research
Publication : Protein engineering

Maltodextrin-binding protein hybrids carrying epitopes from the preS2 region of hepatitis B virus: expression, antibody-binding and preliminary crystallographic studies

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Protein engineering - 01 Feb 1997

Vulliez-le Normand B, Saul FA, Martineau P, Lema F, Hofnung M, Bentley GA

Link to Pubmed [PMID] – 9089817

Protein Eng. 1997 Feb;10(2):175-80

Five hybrid constructions of maltodextrin-binding protein (MBP), each containing an inserted epitope(s) from the preS2 region of the envelope proteins of hepatitis B virus (HBV), have been expressed. The anti-preS2 monoclonal antibody S2.3 was shown to cross-react with the MBP hybrid constructions, demonstrating that the epitopes presented by these recombinant proteins mimic the antigenic behaviour of the native viral antigen. In addition, all five hybrid proteins have been crystallized. Preliminary structural solutions obtained by molecular replacement indicate that the native conformation of MBP is preserved in the hybrid constructions despite the significant length of the epitope insertions.