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© Research
Publication : Environmental Toxicology and Pharmacology

Lungs: Remote inflammatory target of systemic cadmium administration in rats

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Environmental Toxicology and Pharmacology - 01 Sep 2009

Milena Kataranovski, Ivana Mirkov, Sandra Belij, Miroslav Nikolic, Lidija Zolotarevski, Danica Ciric, Dragan Kataranovski

Link to Pubmed [PMID] – 21784007

Environ Toxicol Pharmacol. 2009 Sep;28(2):225-31.

Pulmonary inflammation is a biological response to cadmium entering the body via the respiratory route. Systemic administration of this metal revealed the lungs as a significant site of its disposition. In this study, the presence of basic indicators of lung inflammation (leukocyte infiltration and activity of cells recovered from lungs by enzyme digestion) was analyzed in the rat model of acute systemic cadmium intoxication. Intraperitoneal administration of both cadmium doses (0.5mg/kg and 1.0mg/kg) resulted in increased numbers of neutrophils. Signs of spontaneous activation of lung cells including the capacity of reduction of nitroblue tetrazolium (NBT), increase in myeloperoxidase (MPO) intracellular content and increase in interleukin-6 (IL-6) production were noted at both cadmium doses. Increased lung cell responsiveness to stimulation in vitro was noted at the higher cadmium dose. The presence of pulmonary inflammatory parameters in rats administered intraperitoneally with cadmium revealed the lungs as remote inflammatory targets of this metal.

https://linkinghub.elsevier.com/retrieve/pii/S1382-6689(09)00075-1