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  • Director of Center
  • Director of Department
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© Research
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Viruses - 30 Oct 2009

Benhenda S, Cougot D, Neuveut C, Buendia MA

Link to Pubmed [PMID] – 21994562

Viruses 2009 Dec;1(3):630-46

Epidemiological studies have provided overwhelming evidence for a causal role of chronic HBV infection in the development of hepatocellular carcinoma (HCC), but the molecular mechanisms underlying virally-induced tumorigenesis remain largely debated. In the absence of a dominant oncogene encoded by the HBV genome, indirect roles have been proposed, including insertional activation of cellular oncogenes by HBV DNA integration, induction of genetic instability by viral integration or by the regulatory protein HBx, and long term effects of viral proteins in enhancing immune-mediated liver disease. In this chapter, we discuss different models of HBV-mediated liver cell transformation based on animal systems of hepadnavirus infection as well as functional studies in hepatocyte and hepatoma cell lines. These studies might help identifying the cellular effectors connecting HBV infection and liver cell transformation.

http://www.ncbi.nlm.nih.gov/pubmed/21994562