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© Pierre Gounon
Entrée de Listeria dans une cellule épithéliale (Grossissement X 10000). Image colorisée.
Publication : The Journal of infectious diseases

LapB, a novel Listeria monocytogenes LPXTG surface adhesin, required for entry into eukaryotic cells and virulence

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of infectious diseases - 15 Aug 2010

Reis O, Sousa S, Camejo A, Villiers V, Gouin E, Cossart P, Cabanes D

Link to Pubmed [PMID] – 20617901

J. Infect. Dis. 2010 Aug;202(4):551-62

Attachment to mucosal surfaces is the initial event in the pathogenesis of the human foodborne pathogen Listeria monocytogenes. By use of comparative genomics, we identified a L. monocytogenes-specific gene, lapB, that encodes an LPXTG surface protein that is absent from nonpathogenic Listeria species. We showed that lapB expression is positively regulated by PrfA, the major transcriptional activator of the virulence genes of Listeria species, and is up-regulated in mouse spleens during infection. We demonstrated that LapB is an SrtA-anchored surface protein required for adhesion to and entry into mammalian cells and for virulence following intravenous or oral inoculation in mice. Our results highlight LapB as a new L. monocytogenes virulence adhesin with a function that is supported by its unique N-terminal domain through the probable interaction with a cellular receptor.

http://www.ncbi.nlm.nih.gov/pubmed/20617901