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© Christelle Durand
Microscopie d'un neurone. Le marquage jaune montre les synapses.
Publication : Trends in genetics : TIG

Key role for gene dosage and synaptic homeostasis in autism spectrum disorders

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Trends in genetics : TIG - 06 Jul 2010

Toro R, Konyukh M, Delorme R, Leblond C, Chaste P, Fauchereau F, Coleman M, Leboyer M, Gillberg C, Bourgeron T

Link to Pubmed [PMID] – 20609491

Trends Genet. 2010 Aug;26(8):363-72

Autism spectrum disorders (ASD) are characterized by impairments in reciprocal social communication, and repetitive, stereotyped verbal and non-verbal behaviors. Genetic studies have provided a relatively large number of genes that constitute a comprehensive framework to better understand this complex and heterogeneous syndrome. Based on the most robust findings, three observations can be made. First, genetic contributions to ASD are highly heterogeneous and most probably involve a combination of alleles with low and high penetrance. Second, the majority of the mutations apparently affect a single allele, suggesting a key role for gene dosage in susceptibility to ASD. Finally, the broad expression and function of the causative genes suggest that alteration of synaptic homeostasis could be a common biological process associated with ASD. Understanding the mechanisms that regulate synaptic homeostasis should shed new light on the causes of ASD and could provide a means to modulate the severity of the symptoms.

http://www.ncbi.nlm.nih.gov/pubmed/20609491