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© Research
Publication : Analytical chemistry

Investigation of silicon-based nanostructure morphology and chemical termination on laser desorption ionization mass spectrometry performance.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Analytical chemistry - 18 Dec 2012

Dupré M, Enjalbal C, Cantel S, Martinez J, Megouda N, Hadjersi T, Boukherroub R, Coffinier Y,

Link to Pubmed [PMID] – 23163782

Link to DOI – 10.1021/ac3021104

Anal Chem 2012 Dec; 84(24): 10637-44

We have evaluated the laser desorption ionization mass spectrometry (LDI-MS) performance of six nanostructured silicon surfaces of different morphologies and chemical functionalizations. The substrates have been synthesized either by metal-assisted etching method or by vapor-liquid-solid (VLS) growth technique. In addition to the commercial nanostructured silicon-based surface (NALDI) target plates, serving as reference, the homemade surfaces have been evaluated in mass spectrometry experiments conducted with peptide solutions mimicking tryptic digests. LDI surfaces synthesized by metal-assisted etching method were the most efficient in terms of signal intensities and number of detected peptides. The surface providing the best LDI-MS performance was composed of two nanostructured layers. Interestingly, we also observed a significant influence of the type of organic coating (hydrocarbon vs fluorocarbon) on peptide ionization discrimination.

https://pubmed.ncbi.nlm.nih.gov/23163782