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© Thierry Blisnick & Philippe Bastin, Institut Pasteur
Bloodstream Trypanosoma brucei cell
Publication : Cellular microbiology

Intravital microscopy: Imaging host-parasite interactions in lymphoid organs.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cellular microbiology - 01 Dec 2019

De Niz M, Meehan GR, Tavares J,

Link to Pubmed [PMID] – 31512335

Link to DOI – 10.1111/cmi.13117

Cell Microbiol 2019 12; 21(12): e13117

Intravital microscopy allows imaging of biological phenomena within living animals, including host-parasite interactions. This has advanced our understanding of both, the function of lymphoid organs during parasitic infections, and the effect of parasites on such organs to allow their survival. In parasitic research, recent developments in this technique have been crucial for the direct study of host-parasite interactions within organs at depths, speeds and resolution previously difficult to achieve. Lymphoid organs have gained more attention as we start to understand their function during parasitic infections and the effect of parasites on them. In this review, we summarise technical and biological findings achieved by intravital microscopy with respect to the interaction of various parasites with host lymphoid organs, namely the bone marrow, thymus, lymph nodes, spleen and the mucosa-associated lymphoid tissue, and present a view into possible future applications.

https://pubmed.ncbi.nlm.nih.gov/31512335