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© Fabrice Chrétien with Ultrapole, colorized by Jean-Marc Panaud
Cellule souche (en jaune) de muscle squelettique partiellement recouverte par la membrane basale, migrant sur une fibre musculaire (en bleu).
Publication : Journal of virology

Infection of class II-deficient mice by the DA strain of Theiler’s virus

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of virology - 01 Jul 1996

Fiette L, Brahic M, Pena-Rossi C

Link to Pubmed [PMID] – 8676513

J. Virol. 1996 Jul;70(7):4811-5

The DA strain of Theiler’s virus causes, in susceptible strains of mice, a persistent infection of the white matter of the spinal cord accompanied by chronic inflammation and primary demyelination. In resistant strains, including all H-2b strains, mice clear the infection after 1 to 2 weeks. We inoculated RHAbetao/o mice, an H-2b strain which does not express class II molecules. We found that they are susceptible to persistent infection and that they develop foci of chronic inflammation with demyelination. However, these foci are smaller and contain fewer demyelinated axons than those observed in susceptible SJL/J or beta2m-/- mice.

http://www.ncbi.nlm.nih.gov/pubmed/8676513