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© Institut Pasteur
Macrophages et lymphocytes de souris. Image colorisée.
Publication : Development (Cambridge, England)

Immature hematopoietic stem cells undergo maturation in the fetal liver

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Development (Cambridge, England) - 16 Aug 2012

Kieusseian A, Brunet de la Grange P, Burlen-Defranoux O, Godin I, Cumano A

Link to Pubmed [PMID] – 22899849

Development 2012 Oct;139(19):3521-30

Hematopoietic stem cells (HSCs), which are defined by their capacity to reconstitute adult conventional mice, are first found in the dorsal aorta after 10.5 days post coitus (dpc) and in the fetal liver at 11 dpc. However, lympho-myeloid hematopoietic progenitors are detected in the dorsal aorta from 9 dpc, raising the issue of their role in establishing adult hematopoiesis. Here, we show that these progenitors are endowed with long-term reconstitution capacity, but only engraft natural killer (NK)-deficient Rag2γc(-/-) mice. This novel population, called here immature HSCs, evolves in culture with thrombopoietin and stromal cells, into HSCs, defined by acquisition of CD45 and MHC-1 expression and by the capacity to reconstitute NK-competent mice. This evolution occurs during ontogeny, as early colonization of fetal liver by immature HSCs precedes that of HSCs. Moreover, organ culture experiments show that immature HSCs acquire, in this environment, the features of HSCs.

http://www.ncbi.nlm.nih.gov/pubmed/22899849