Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
© Institut Pasteur
Macrophages et lymphocytes de souris. Image colorisée.
Publication : Journal of leukocyte biology

Identification of CD4int progenitors in mouse fetal spleen, a source of resident lymphoid cells

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of leukocyte biology - 12 Feb 2008

Desanti GE, Cumano A, Golub R

Link to Pubmed [PMID] – 18270249

J. Leukoc. Biol. 2008 May;83(5):1145-54

Hematopoiesis occurs in different tissues during adult and fetal life. Splenic hematopoiesis arises in the fetal period until the first weeks of life. We have analyzed the hematopoietic progenitor content of the fetal spleen (FS) at the embryonic days 14.5-15.5. We first demonstrate that the hematopoietic content of the FS differs largely from its fetal liver (FL) counterpart. The difference mainly concerns the distribution of the different pool of progenitors, as most of the splenic progenitors are comprised in the lineage(-)Sca1(-)cKit(lo) contrary to the FL. We have divided the fetal hematopoietic pool into smaller fractions to enable characterization of the earliest lymphoid progenitors. Among the lymphoid progenitors that already represent a rare population, we were able to separate a population, respectively, enriched in B or T/NK progenitors. Lineage restriction of the different developmental intermediates was tested by clonal assays. We propose a model for fetal splenic hematopoietic progenitors and their distribution.

http://www.ncbi.nlm.nih.gov/pubmed/18270249